Well, here we go (for real this time).
It’s been almost a year since we started the journey and the next chapter starts on the 8/10/2017. That’s when my next trip to Chicago starts 8/10/2107 and I’ll do what is called “Mobilization”. Here’s all the details of this process…
“What is stem cell mobilization?
The purpose of stem cell mobilization is to prepare the body for collection of stem cells. Normally, the bone marrow releases only a small number of stem cells into the peripheral blood circulation. In order to obtain enough stem cells in the blood to harvest for a stem cell transplant, certain medications are used to encourage the movement (or mobilization) of stem cells from the bone marrow into the peripheral blood so they can be collected.”
What Medications are used for Mobilization?
- A chemotherapy drug that is an alkylating agent and immunosuppressant.
- The medication is infused intravenously (through an IV)
- Cyclophosphamide suppresses the immune system and helps mobilize stem cells out of the bone marrow into the peripheral blood.
- The infusion will require a 24 hour stay in the hospital.
- The cyclophosphamide infusion will take 2 hours, however IV fluids and a medication called mesna will infuse through an IV for a total of 24 hours. Mesna is a medication that helps protect the bladder (see side effects below).
- The dose is based on weight and height.
G-CSF (Granulocyte colony stimulating factor) Neupogen,
TBO- filgrastim (Granix)
- G-CSF is used to treat neutropenia, or low neutrophils. It also helps mobilize stem cells into the peripheral blood system for collection.
- G-CSF is given as a subcutaneous injection. The needles used to give the injection are very small.
- The medication will start five days after receiving the cyclophosphamide and will continue daily until the stem cell harvest is complete.
- The dose is 5-10 mcg/ kg Must be kept in the refrigerator until ready for use.